Endocrine Abstracts

Introduction: Intensive insulin treatment regimens, multiple daily injections (MDI) and continuous subcutaneous insulin infusions (CSII) are used widely in the NHS, despite a lack of evidence that more expensive treatment with CSII is superior to MDI. In this presentation, data from previous observational and interventional studies will be reviewed. The findings of the SCIPI study (SubCuntaneous Insulin: Pumps or Injections?), which compared the effectiveness, safety, quality ...

Background: During childhood, growth hormone (GH) doses are usually calculated using total body weight (TBW). This may result in inappropriately high doses in obese children where the intravascular compartment does not increase in proportion with the increase in weight, as the volume of distribution of GH is consistent with the majority of the drug being distributed in the total body water compartment.Methods: Single centre, retrospective cohort study of...

Introduction: In paediatric practice hydrocortisone (HC) is frequently prescribed in doses of ≤2.5 mg. HC tablets are only available in 10 mg strengths or as 2.5 mg Corlan pellets, a formulation designed for oro-mucosal delivery. Thus, tablets are segmented to obtain an appropriate dose. This study examines the accuracy of obtaining 2.5 mg HC doses from quartered tablets.Materials and methods: Of 10 mg Hydrocortone tablets were studied. Weight unif...

The multiple endocrine neoplasia (MEN) clinic at our hospital was established in 2002 with the aim of providing integrated, comprehensive and expert regional care to patients with MEN syndrome. The clinical team consists of an adult endocrinologist, a paediatric endocrinologist, a clinical geneticist and an endocrine surgeon.In 2002, 16 patients with MEN type 1 from five different kindred were seen. These patients had previously been attending a combinat...

Introduction: Hypoparathyroidism is an uncommon condition in children characterized by hypocalcemia and hyperphosphatemia due to defective synthesis /secretion of parathyroid hormone (PTH), end organ resistance or an inappropriately activated calcium-sensing receptor (CaSR). Clinical symptoms include muscle spasms, stridor, seizures, and syncope. It is rare for a child with this condition to present with cardiac failure at diagnosis. The therapeutic approaches...

Background: Biochemical evidence of adrenal insufficiency (AI) is reported commonly during inhaled corticosteroid (ICS) treatment for asthma. The significance of mildly abnormal results is uncertain. For this reason we adopt a stratified approach to the management of patients with impaired cortisol responses to the low dose short Synacthen test (LDSST): Patients with peak cortisol 350–499 nmol/l (‘suboptimal’) receive hydrocortisone 20 mg/m2 per day d...

Introduction: Anti-thyroid medications are the first line therapy for children and young people with Grave’s disease (GD). Some studies have shown remission rates up to 40–50%; however long-term follow up studies have reported much lower remission rates in children compared to adults.Aim: To review the long-term follow up and management of adolescents with Grave’s disease in a single tertiary centre in the UK.Methods...

Objective: To describe real-world safety data on growth hormone therapy (GHT) in paediatric patients with Noonan syndrome (NS) who were enrolled in NordiNet® IOS and the ANSWER®Program.Introduction: Patients with NS have a high prevalence of cardiac defects and an increased risk for leukaemia and certain malignancies compared to the general population. Current safety data do not indicate an association of GHT with worsenin...

Background: Early diagnosis of girls with turner syndrome (TS) is essential to provide timely intervention and support. The screening guidelines for TS suggest karyotype evaluation in patients presenting with short stature, webbed neck, lymphoedema, coarctation of aorta or >two dysmorphic features (nail dysplasia, high arched palate, short fourth metacarpal or strabismus).Objectives: The aim of the study was to determine the age and clinical features...

Background: Adolescent polycystic ovarian syndrome (PCOS) is being diagnosed more frequently as the prevalence of childhood obesity increases. Adolescent PCOS has been associated with low birth weight (LBW), exaggerated adrenarche (EA) and metabolic syndrome in Mediterranean populations. This study describes the clinical phenotype of a cohort of northern European girls.Methods: A retrospective study of adolescents with PCOS, diagnosed according to the Ro...